Cleaning a hiking backpack: Osprey's hand-wash and shade-dry guide
Empty the pack, detach removable belts and gently hand-wash with mild detergent. Osprey does not recommend machine washing and advises air-drying in ventilation away from direct sun.
After a hike, check the pack's care instructions before removing sweat or mud. Osprey's official guide explains detachable-part preparation, mild warm soapy-water cleaning, thorough rinsing and ventilated shade-drying. Wheeled High Road chassis packs must not be immersed; some specialty models require their own instructions. Use only the recommended gentle detergent and never mix cleaners.